Q.1
Proto-oncogenes can be transformed to oncogenes by all of the following mechanisms except _____________
  • a) Elimination of their start signals for translation
  • b) During a viral infection cycle
  • c) Chromosomal rearrangements
  • d) Chemically induced mutagenesis
Q.2
Oncogenes do not encode for ___________
  • a) Trans-membrane protein receptors
  • b) Growth factors
  • c) DNA-dependent RNA polymerase
  • d) Cytoplasmic G-proteins and protein kinases
Q.3
Programmed cell death is termed as ___________
  • a) Metastasis
  • b) Apoptosis
  • c) Proliferation
  • d) Mitotic termination
Q.4
Which of the following could be coded by a tumor-supressor gene?
  • a) A protein that helps prevent progression through cell cycle
  • b) A protein that helps prevent apoptosis
  • c) A protein that codes for a DNA repair enzyme
  • d) A protein that forms part of a growth factor signaling pathway
Q.5
How does Ras oncogene contribute to cancers?
  • a) It codes for an anti-apoptotic protein, produced in abnormally large amounts
  • b) It codes for a GTPase switch protein, which in its mutated form cannot be switched off
  • c) It codes for a transcription factor produced abnormally in large amounts
  • d) A growth factor that is continually active is encoded in its truncated form
Q.6
Which property of penables it to prevent the development of cancer?
  • a) It is a transcription factor that causes protein production which stimulates the cell cycle
  • b) It prevents replication of cells with damaged DNA
  • c) It prevents cells from triggering apoptosis
  • d) It stimulates synthesis of DNA repair enzymes that replace telomere sequence lost during cell division
Q.7
The characteristic of malignant other than a benign tumor is?
  • a) Undergoes metastasis
  • b) Develops blood supply
  • c) Cell divides an unlimited number of times
  • d) Grows without needing a growth signal
Q.8
The mutation which cannot give rise to an oncogene?
  • a) Addition or deletion of a base producing a nonsense message and an inactive protein product
  • b) A point mutation changing just one amino acid in protein product
  • c) A translocation, putting gene under control of strong promoter producing over expression
  • d) A point mutation producing stop codon, premature termination
Q.9
Which of the following about Rb tumor suppressor protein is correct?
  • a) It binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received
  • b) It is activated when phosphorylated by Cdk
  • c) It is a transcription factor
  • d) When a mitogenic signal is received, it binds the transcription factor E2F and thus stimulates the cell to enter S phase
Q.10
Migration of cancerous cells from the site of origin to other part of the body forming secondary tumors is called ___________
  • a) Diapedesis
  • b) Metastasis
  • c) Proliferation
  • d) Apoptosis
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