Q.1
Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______
  • a) single gene in at least one genome
  • b) multiple genes in at least one genome
  • c) multiple genes in various genomes
  • d) single gene in various genomes
Q.2
Experimentation is most desirable over computational methods by every means.
  • a) True
  • b) False
Q.3
Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.
  • a) True
  • b) False
Q.4
When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.
  • a) True
  • b) False
Q.5
Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.
  • a) True
  • b) False
Q.6
In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.
  • a) True
  • b) False
Q.7
Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.
  • a) not applicable to archea genomes
  • b) not applicable to prokaryote genomes
  • c) applicable to eukaryote genomes
  • d) not applicable to eukaryote genomes
Q.8
An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.
  • a) gene interactions, only three to four orthologs
  • b) gene interactions, two orthologs
  • c) protein interactions, two or more orthologs
  • d) protein interactions, two orthologs
Q.9
Domains that are part of a multidomain protein are ______
  • a) nethier co-regulated nor colocalized
  • b) not co-regulated but colocalized
  • c) co-regulated and but not colocalized
  • d) co-regulated and colocalized
Q.10
Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.
  • a) True
  • b) False
Q.11
The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.
  • b) False
  • a) True
Q.12
In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.
  • a) True
  • b) False
Q.13
In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.
  • a) True
  • b) False
Q.14
Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.
  • a) True
  • b) False
Q.15
The most detailed experimental information about protein-protein interactions comes from three-dimensional structures.
  • a) True
  • b) False
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