Q.1
In the program COGNITOR each protein in the proteome is used as a query of a database of protein clusters.
  • a) True
  • b) False
Q.2
WU-BLAST produces P scores and BLAST (NCBI) produces E scores where _________
  • a) E = ln (1 + P2)
  • b) E = ln (1 – P2)
  • c) E = ln (1 + P)
  • d) E = ln (1 – P)
Q.3
In Proteolysis and fragment sequencing, Protein spots may be excised from a two-dimensional protein gel and subjected to a combination of amino acid sequencing and cleavage analyses using the techniques of mass spectrometry and high-pressure liquid chromatography.
  • a) True
  • b) False
Q.4
In Proteingel Electrophoresis, Individual proteins produced by the genome can be separated to _____ by this method and specific ones identified by various _______
  • a) smaller extent, biochemical and immunological tests
  • b) a large extent, biochemical and immunological tests
  • c) a large extent, biochemical tests only
  • d) smaller extent, purely mechanical tests
Q.5
In Metabolic pathways and regulation, as genes are identified in a new genome sequence, some will be found that are known to act sequentially in a metabolic pathway or to have a known role in gene regulation in other organisms.
  • a) True
  • b) False
Q.6
_______ of the Drosophila sequence is composed of TEs and _____ is heterochromatic regions that do not include genes.
  • a) one-fourth, one-third
  • b) one-fifth, one-fourth
  • c) one-sixth, one-eighth
  • d) one-sixth, one-third
Q.7
Yeast is about ______ compact than E. coli.
  • a) fivefold, less
  • b) threefold, more
  • c) twofold, less
  • d) twofold, more
Q.8
The ________ are _______ by genetic structure to retroviruses.
  • a) STR retrotransposons, related
  • b) LTR retrotransposons, related
  • c) STR transposons, related
  • d) LTR retrotransposons, not related
Q.9
Which of the given statement is incorrect?
  • a) As in an all-by-all protein comparison within a proteome, a matrix of alignment scores with E values is made, and the most closely related sequences in the two organisms are identified
  • b) To perform a between-proteome analysis, proteome databases are made for the known and predicted genes of two or more genomes
  • c) Each protein of one proteome is selected in turn as a query of the proteome of another organism or the combined proteome of a group of organisms
  • d) Each protein of one proteome is selected in turn as a query of the proteome of another single organism only
Q.10
The higher the E value, the more significant the alignment between a pair of matching sequences.
  • a) True
  • b) False
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