Q.1
Which of the following is untrue regarding the transmembrane proteins?
  • a) The membrane proteins are also of tremendous biomedical importance
  • b) They are not drug targets or receptors
  • c) They are responsible for performing a wide variety of important functions in a cell, such as signal transduction, cross-membrane transport, and energy conversion
  • d) Constitute up to 30% of all cellular proteins
Q.2
Which of the following is wrong about National Biomedical Research Foundation/Protein Information Resource Sequence Format?
  • a) This is different than PIR format
  • b) The first line includes an initial “>” character followed by a two-letter code such as P for complete sequence or F for the fragment, followed by a 1 or 2 to indicate type of sequence, then a semicolon, then a four- to six-character unique name for the entry
  • c) The NBRF format is similar to the FASTA sequence format but with significant differences
  • d) Sequences retrieved from the PIR database are not in this compact format, but in an expanded format with much more information about the sequence
Q.3
Which of the following is incorrect about ENTREZ?
  • a) It provides a series of forms that can be filled out to retrieve a Medline reference related to the molecular biology sequence databases
  • b) It provides a series of forms that can be filled out to retrieve a DNA or protein sequence
  • c) It is a resource prepared only by the staff of the National Center for Biotechnology Information
  • d) One straightforward way to access the sequence databases is through ENTREZ
Q.4
In medical applications, the ultimate goal of gene mapping is to disease genes.
  • a) False
  • b) True
Q.5
Which of the following does not describe local alignment algorithm?
  • a) In traceback step, beginning is with the highest score, it ends when 0 is encountered
  • b) First row and first column are set to 0 in initialization step
  • c) Score can be negative
  • d) Negative score is set to 0
Q.6
Which of the following is an abbreviation of MEME?
  • a) Multiple Expectation Maximization for Motif Extraction
  • b) Mega Expectation Maximization for Motif Elicitation
  • c) Micro Expectation Maximization for Motif Extraction
  • d) Multiple Expectation Maximization for Motif Elicitation
Q.7
Which of the following is not a software for dot plot analysis?
  • a) DOTMATCHER
  • b) LALIGN
  • c) DOTLET
  • d) SIMMI
Q.8
Which of the following is not a site on internet for alignment of sequence pairs?
  • a) BLASTN
  • b) BCM Search Launcher
  • c) BLASTX
  • d) SIM
Q.9
Which of the following is true regarding the assumptions in the method of constructing the Dayhoff scoring matrix?
  • a) sites do not vary in their degree of mutability
  • b) it is assumed that each amino acid position is equally mutable
  • c) it is assumed that each amino acid position is not equally mutable
  • d) it is assumed that each amino acid position is not mutable at all
Q.10
Which of the following feature of Bayesian methods is the disadvantage?
  • a) A specific mutational model is required
  • b) Computationally Bayesian methods are better
  • c) A length and distance that gives the highest overall probability may be determined
  • d) They are used to calculate evolutionary distance
Q.11
Which of the following is incorrect regarding sequence homology?
  • a) It is an important concept in sequence analysis
  • b) When two sequences are descended from a common evolutionary origin, they are said to share homology
  • c) Two sequences can homologous relationship even if have do not have common origin
  • d) When two sequences are descended from a common evolutionary origin, they are said to have a homologous relationship
Q.12
The presence of evolutionary traces is because some of the residues that perform key functional and structural roles tend to be preserved by natural selection; other residues that may be less crucial for structure and function tend to mutate more frequently.
  • a) True
  • b) False
Q.13
A sequence can be aligned with itself to identify internal repeat elements.
  • a) True
  • b) False
Q.14
What is used to generate parameters for the extreme distribution?
  • a) The pool of alignment scores from the unshuffled sequences
  • b) The pool of alignment scores from the shuffled sequences
  • c) The basic optimal score computed at the beginning of the test
  • d) A single score of a shuffled sequence
Q.15
The major disadvantage of the PRSS program is that it doesn’t allow partial shuffling.
  • a) True
  • b) False
Q.16
Which of the following scores are not considered while calculating the SP scores?
  • a) Number of gap penalties
  • b) All possible pair wise matches
  • c) All possible mismatches
  • d) All possible gap costs
Q.17
Which of the following is untrue about the iterative approach?
  • a) Because the order of the sequences used for alignment is different in each iteration
  • b) This method is not based on heuristic methods
  • c) The iterative approach is based on the idea that an optimal solution can be found by repeatedly modifying existing suboptimal solutions
  • d) This method is also heuristic in nature and does not have guarantees for finding the optimal alignment
Q.18
Which of the following is not the objective to perform sequence comparison?
  • a) To find the common motifs present in both sequences
  • b) To study the physical properties of molecules
  • c) To study evolutionary relationships
  • d) To observe patterns of conservation
Q.19
The initial alignments used to produce the guide tree may be obtained by various methods. Which of the following is not one of them?
  • a) pattern-finding approach similar
  • b) FASTA
  • c) Faster, full dynamic programming method
  • d) Fast k-tuple
Q.20
In Genetic Algorithm, in the mutation process _______
  • a) sequence is not changed
  • b) sequence is changed
  • c) gaps are not rearranged
  • d) gaps are not inserted
0 h : 0 m : 1 s