Q.1
Which of the following is not among the methods for finding localized sequence similarity?
  • a) Extraction of Blocks from a Global or Local MSA
  • b) Pattern blocking
  • c) Block Analysis
  • d) Profile Analysis
Q.2
For the 10-residue DNA sequence example, there are _______ possible starting sites for a 20-residue-long site.
  • a) 70
  • b) 51
  • c) 81
  • d) 40
Q.3
MACAW is a local multiple sequence alignment program and a sequence editing tool.
  • a) True
  • b) False
Q.4
Which of the following is not one of the requirements for implementing algorithms for sequence database searching?
  • c) Sensitivity
  • a) Speed
  • b) Size of the dataset
  • d) Specificity
Q.5
Which of the following is not a variant of BLAST?
  • a) BLASTX
  • b) TBLASTNX
  • c) BLASTP
  • d) BLASTN
Q.6
Which of the following is not correct about FASTA?
  • a) It was in fact the first database similarity search tool developed, preceding the development of BLAST
  • b) FASTA uses a ‘hashing’ strategy to find matches for a short stretch of identical residues with a length of k
  • c) The string of residues is known as blocks
  • d) Its stands for FAST ALL
Q.7
Which of the following is not a benefit of BLAST?
  • a) Speed
  • b) Statistical rigor
  • c) Handling of gaps
  • d) More sensitive
Q.8
Which of the following is not correct about the Coils and Loops?
  • a) They are irregular structures
  • b) If the connecting regions are completely irregular, they belong to random coils
  • c) They are regular structures
  • d) The loops are often characterized by sharp turns or hairpin-like structures
Q.9
Which of the following is an incorrect statement?
  • a) Molscript is not capable of generating ball-and-stick styles
  • b) In particular, secondary structure elements can be drawn with solid spirals and arrows representing α-helices and β-strands, respectively
  • c) Molscript is capable of generating space-filling
  • d) Molscript is a UNIX program capable of generating wire-frame
Q.10
Which of the following is untrue about SCOP?
  • a) It is constructed almost entirely based on manual examination of protein structures
  • b) The SCOP families consist of proteins having low sequence identity (>30%)
  • c) It is a database for comparing and classifying protein structures
  • d) The proteins are grouped into hierarchies of classes, folds, superfamilies, and families
Q.11
Which of the following is untrue regarding Prediction with Neural Networks?
  • a) A neural network is trained by a single sequence
  • b) When the sufficiently trained network processes an unknown sequence, it applies the rules learned in training to recognize particular structural patterns
  • c) When multiple sequence alignments and neural networks are combined, the result is further improved accuracy
  • d) A neural network is trained by a sequence profile derived from the multiple sequence alignment
Q.12
Which of the following is true regarding Coiled coil?
  • a) They have an integral repeat of seven residues
  • b) They have an integral repeat of thirty residues
  • c) The sequence periodicity doesn’t contribute in designing algorithms to predict the structural domain
  • d) They have an integral repeat of twenty residues
Q.13
Which of the following is untrue regarding Chou–Fasman and GOR methods?
  • a) They suffer from the fact that the prediction rules are somewhat arbitrary
  • b) They are based on single sequence statistics with clear relation to known protein-folding theories
  • c) They are developed in the 1970s
  • d) Both are the first-generation methods
Q.14
Which of the following is untrue about homology modeling?
  • a) It doesn’t involve the evolutionary distances anywhere
  • b) The principle behind it is that if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures
  • c) Homology modeling predicts protein structures based on sequence homology with known structures
  • d) It is also known as comparative modeling
Q.15
In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.
  • a) energy-based
  • b) residue-based
  • c) structure-based
  • d) sequence-based
Q.16
Which of the following is untrue about Loop Modeling Step?
  • a) The gaps cannot be directly modeled
  • b) Loop modeling is required for closing the gaps requires
  • c) In the sequence alignment for modeling, there are no regions producing gaps in sequence alignment
  • d) In the sequence alignment for modeling, there are often regions caused by insertions and deletions producing gaps in sequence alignment
Q.17
Which of the following is not a form of RNA?
  • a) tRNA
  • b) rRNA
  • c) mRNA
  • d) qRNA
0 h : 0 m : 1 s