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Drug Pharmaceutical Biotechnology
Drug Biotechnology Objective
Quiz 1
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Q.1
Which of the following is not a factor of renal excretion?
a) Blood flow to the kidneys
b) Urine pH
c) Blood pH
d) Disease state
Q.2
Which of the following is not a physicochemical factor of drug that can affect the renal excretion?
a) Molecular size
b) Disintegration rate
c) pKa of the drug
d) Lipid solubility
Q.3
Drugs of molecular range 300-Dalton will be excreted out by glomerulus.
a) True
b) False
Q.4
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve?
a) Drug excreted only by filtration
b) Drug filtered and actively reabsorbed
c) Drug filtered as well as actively secreted
d) Drug reabsorbed actively
Q.5
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve?
a) Drug excreted only by filtration
b) Drug filtered and actively reabsorbed
c) Drug filtered as well as actively secreted
d) Drug reabsorbed actively
Q.6
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve? (x axis- rate of excretion, y axis – plasma drug concentration)
a) Drug excreted only by filtration
b) Drug filtered and actively reabsorbed
c) Drug filtered as well as actively secreted
d) Drug reabsorbed actively
Q.7
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?
a) Drug excreted only by filtration
b) Drug filtered and actively reabsorbed
c) Drug filtered as well as actively secreted
d) Drug reabsorbed actively
Q.8
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?
a) Drug excreted only by filtration
b) Drug filtered and actively reabsorbed
c) Drug filtered as well as actively secreted
d) Drug reabsorbed actively
Q.9
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?
a) Drug excreted only by filtration
b) Drug filtered and actively reabsorbed
c) Drug filtered as well as actively secreted
d) Drug reabsorbed actively
Q.10
Clearance is inversely related to volume of distribution.
a) True
b) False
Q.11
Which drugs cannot be filtered through glomerulus?
a) Drugs bound to plasma proteins
b) Unbound
c) Free drug
d) Below molecular weight of 300 Dalton
Q.12
Which one is the correct equation to calculate the fraction of unbound drug in plasma?
a) Concentration of unbound drug in plasma / total plasma concentration of drug
b) Total plasma concentration of drug / Concentration of unbound drug in plasma
c) 1/Concentration of unbound drug in plasma
d) 1/total plasma concentration of drug
Q.13
What will be the fraction of unbound drug if the unbound drug concentration is 0.g/ml and total plasma concentration isg/ml?
a) 0.006
b) 1.61
c) 0.618
d) 0.010
Q.14
What will be the unbound drug concentration if the unbound drug fraction is 0.and the total plasma concentration isg/ml?
a) 80 g/ml
b) 82.8 g/ml
c) 70 g/ml
d) 72.8 g/ml
Q.15
Age, sex, species, differences in genetic makeup alter drug excretion.
a) True
b) False
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