Q.1
Which of the following is not a factor of renal excretion?
  • a) Blood flow to the kidneys
  • b) Urine pH
  • c) Blood pH
  • d) Disease state
Q.2
Which of the following is not a physicochemical factor of drug that can affect the renal excretion?
  • a) Molecular size
  • b) Disintegration rate
  • c) pKa of the drug
  • d) Lipid solubility
Q.3
Drugs of molecular range 300-Dalton will be excreted out by glomerulus.
  • a) True
  • b) False
Q.4
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve?
Questiondrug-pharmaceutical-biotechnology-questions-answers4.jpg
  • a) Drug excreted only by filtration
  • b) Drug filtered and actively reabsorbed
  • c) Drug filtered as well as actively secreted
  • d) Drug reabsorbed actively
Q.5
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve?
Questiondrug-pharmaceutical-biotechnology-questions-answers5.jpg
  • a) Drug excreted only by filtration
  • b) Drug filtered and actively reabsorbed
  • c) Drug filtered as well as actively secreted
  • d) Drug reabsorbed actively
Q.6
In a graph of rate of excretion versus plasma drug concentration, which kind of drug will give the below shown curve? (x axis- rate of excretion, y axis – plasma drug concentration)
Questiondrug-pharmaceutical-biotechnology-questions-answers6.jpg
  • a) Drug excreted only by filtration
  • b) Drug filtered and actively reabsorbed
  • c) Drug filtered as well as actively secreted
  • d) Drug reabsorbed actively
Q.7
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?
Questiondrug-pharmaceutical-biotechnology-questions-answers7.jpg
  • a) Drug excreted only by filtration
  • b) Drug filtered and actively reabsorbed
  • c) Drug filtered as well as actively secreted
  • d) Drug reabsorbed actively
Q.8
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?
Questiondrug-pharmaceutical-biotechnology-questions-answers8.jpg
  • a) Drug excreted only by filtration
  • b) Drug filtered and actively reabsorbed
  • c) Drug filtered as well as actively secreted
  • d) Drug reabsorbed actively
Q.9
In a graph of renal clearance versus plasma drug concentration, which kind of drug will give the below shown curve?
Questiondrug-pharmaceutical-biotechnology-questions-answers9.jpg
  • a) Drug excreted only by filtration
  • b) Drug filtered and actively reabsorbed
  • c) Drug filtered as well as actively secreted
  • d) Drug reabsorbed actively
Q.10
Clearance is inversely related to volume of distribution.
  • a) True
  • b) False
Q.11
Which drugs cannot be filtered through glomerulus?
  • a) Drugs bound to plasma proteins
  • b) Unbound
  • c) Free drug
  • d) Below molecular weight of 300 Dalton
Q.12
Which one is the correct equation to calculate the fraction of unbound drug in plasma?
  • a) Concentration of unbound drug in plasma / total plasma concentration of drug
  • b) Total plasma concentration of drug / Concentration of unbound drug in plasma
  • c) 1/Concentration of unbound drug in plasma
  • d) 1/total plasma concentration of drug
Q.13
What will be the fraction of unbound drug if the unbound drug concentration is 0.g/ml and total plasma concentration isg/ml?
  • a) 0.006
  • b) 1.61
  • c) 0.618
  • d) 0.010
Q.14
What will be the unbound drug concentration if the unbound drug fraction is 0.and the total plasma concentration isg/ml?
  • a) 80 g/ml
  • b) 82.8 g/ml
  • c) 70 g/ml
  • d) 72.8 g/ml
Q.15
Age, sex, species, differences in genetic makeup alter drug excretion.
  • a) True
  • b) False
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