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Drug Pharmaceutical Biotechnology
Drug Biotechnology Written Test
Quiz 1
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Q.1
Which one of the following factors related to protein-drug binding is not related to drugs?
a) Physicochemical characteristics of a drug
b) The concentration of the drug in the body
c) The affinity of the drug for binding
d) Number of binding sites on the binding agent
Q.2
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
a) Competition between the drug and the binding site
b) Competition between drugs and normal body constituents
c) Allosteric changes in a protein molecule
d) Inter subject variation
Q.3
Which of the following factors for protein drug binding is a drug interaction factor?
a) Competition between drugs for the binding site
b) Age
c) Physicochemical characteristics of a drug
d) Physicochemical characteristics of the protein or binding agent
Q.4
Which drugs bind to HSA easily?
a) Cationic drug
b) Anionic drug
c) Lipophilic drug
d) Neutral drug
Q.5
Which drugs easily bind to adipose tissue?
a) Cationic drug
b) Anionic drug
c) Lipophilic drug
d) Neutral drug
Q.6
Which drug easily bind to AAG?
a) Cationic drug
b) Anionic drug
c) Lipophilic drug
d) Neutral drug
Q.7
The extent of drug-protein binding can change with both changes in protein and drug concentration.
a) True
b) False
Q.8
In the equation X= Vd C, what does X stands for?
a) Amount of drug in the blood
b) Amount of drug in plasma
c) Amount of drug in the tablet
d) Amount of drug in the body
Q.9
Only unbound or free drug is capable of being eliminated.
a) True
b) False
Q.10
Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
a) True
b) False
Q.11
What kind of graph is shown in the picture?
a) Direct plot
b) Scatchard plot
c) Double reciprocal plot
d) Michele’s menten plot
Q.12
What kind of graph is shown in the picture?
a) Direct plot
b) Scatchard plot
c) Double reciprocal plot
d) Michele’s menten plot
Q.13
What kind of graph is shown in the picture?
a) Direct plot
b) Scatchard plot
c) Double reciprocal plot
d) Michele’s menten plot
Q.14
Displacement interactions are significant in the case of drugs which are more thanbound.
a) True
b) False
Q.15
Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
a) CuC
b) C / Cu
c) Cu/C
d) 1/C Cu
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