Q.1
Which one of the following factors related to protein-drug binding is not related to drugs?
  • a) Physicochemical characteristics of a drug
  • b) The concentration of the drug in the body
  • c) The affinity of the drug for binding
  • d) Number of binding sites on the binding agent
Q.2
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
  • a) Competition between the drug and the binding site
  • b) Competition between drugs and normal body constituents
  • c) Allosteric changes in a protein molecule
  • d) Inter subject variation
Q.3
Which of the following factors for protein drug binding is a drug interaction factor?
  • a) Competition between drugs for the binding site
  • b) Age
  • c) Physicochemical characteristics of a drug
  • d) Physicochemical characteristics of the protein or binding agent
Q.4
Which drugs bind to HSA easily?
  • a) Cationic drug
  • b) Anionic drug
  • c) Lipophilic drug
  • d) Neutral drug
Q.5
Which drugs easily bind to adipose tissue?
  • a) Cationic drug
  • b) Anionic drug
  • c) Lipophilic drug
  • d) Neutral drug
Q.6
Which drug easily bind to AAG?
  • a) Cationic drug
  • b) Anionic drug
  • c) Lipophilic drug
  • d) Neutral drug
Q.7
The extent of drug-protein binding can change with both changes in protein and drug concentration.
  • a) True
  • b) False
Q.8
In the equation X= Vd C, what does X stands for?
  • a) Amount of drug in the blood
  • b) Amount of drug in plasma
  • c) Amount of drug in the tablet
  • d) Amount of drug in the body
Q.9
Only unbound or free drug is capable of being eliminated.
  • a) True
  • b) False
Q.10
Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
  • a) True
  • b) False
Q.11
What kind of graph is shown in the picture?
Questiondrug-pharmaceutical-biotechnology-questions-answers11.jpg
  • a) Direct plot
  • b) Scatchard plot
  • c) Double reciprocal plot
  • d) Michele’s menten plot
Q.12
What kind of graph is shown in the picture?
Questiondrug-pharmaceutical-biotechnology-questions-answers12.jpg
  • a) Direct plot
  • b) Scatchard plot
  • c) Double reciprocal plot
  • d) Michele’s menten plot
Q.13
What kind of graph is shown in the picture?
Questiondrug-pharmaceutical-biotechnology-questions-answers13.jpg
  • a) Direct plot
  • b) Scatchard plot
  • c) Double reciprocal plot
  • d) Michele’s menten plot
Q.14
Displacement interactions are significant in the case of drugs which are more thanbound.
  • a) True
  • b) False
Q.15
Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
  • a) CuC
  • b) C / Cu
  • c) Cu/C
  • d) 1/C Cu
0 h : 0 m : 1 s