Q.1
Which one of the following is a critical rate-limiting step of drug absorption?
  • a) Rate of drug disintegration
  • b) Size of the drug
  • c) Size of the porous particle
  • d) Rate of dissolution
Q.2
Which sentence will define the Dissolution rate?
  • a) Amount of solid substrate that goes into solution under constant time
  • b) Amount of solid substrate that goes into solution under constant time under standard temperature
  • c) Amount of solid substrate that goes into solution under constant time under standard temperature, pH, and pressure
  • d) Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area
Q.3
What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8?
  • a) 3-4mg/ml
  • b) 4-6 mg/ml
  • c) 7-8 mg/ml
  • d) 1-2 mg/ml
Q.4
Which one of these is not a theory of Drug dissolution?
  • a) Diffusion layer model
  • b) Fick’s law of diffusion
  • c) Penetration or surface renewal theory
  • d) Interfacial barrier model
Q.5
Which theory takes into account that a thin film is created by the solution of the solid at the solid-liquid interface?
  • a) Interfacial barrier model
  • b) Diffusion layer model
  • c) Penetration or surface renewal theory
  • d) Danckwert’s model
Q.6
In the equation G=Ki (Cs-Cb), what does G stands for______________
  • a) Dissolution rate per unit area
  • b) Effective interfacial transport constant
  • c) Concentration of the solute
  • d) Concentration of the impurity
Q.7
Which model does not approve the existence of the stagnant layer in the solid-liquid interface?
  • a) Interfacial barrier model
  • b) Diffusion layer model
  • c) Penetration or surface renewal theory
  • d) Danckwert’s model
Q.8
What does the interfacial barrier model states?
  • a) An intermediate concentration exists at the interface
  • b) Turbulence in the dissolution medium exists at the solid/liquid interface
  • c) Formation a thin film or layer at the solid-liquid interface
  • d) Solutes passes easily through the interfaces
Q.9
In the equation, Wo1/3-W1/3=Kt, K stands for ____________
  • a) The original mass of the drug
  • b) Mass of the drug remaining after time t
  • c) Dissolution constant
  • d) Concentration of solute
Q.10
Which are the two rate-determining step of drug absorption when given orally?
  • a) Disintegration and deaggregation
  • b) Disintegration and Dissolution
  • c) Dissolution and permeation through the membrane
  • d) Permeation through the membrane and Disintegration
Q.11
The maximum amount of solute dissolved in a given solvent under standard conditions of temperature, pressure, and pH is known as __________
  • a) Dissolution rate
  • b) Intrinsic dissolution
  • c) Rate limiting step
  • d) Absolute or intrinsic solubility
Q.12
In the equation, V dC/dt = dm/dt = A(Cs-Cb).√ γ D, what does γ stands for?
  • a) Mass of the solid dissolved
  • b) Rate of surface renewal
  • c) Concentration of solute
  • d) Concentration of the drug
Q.13
Each face of the crystal has a different interfacial barrier.
  • a) True
  • b) False
0 h : 0 m : 1 s