Q.1
B domain of FVIII is necessary for the clotting activity.
  • a) True
  • b) False
Q.2
Which of the following are a successful acute and prophylactic protein bypassing agent for haemophilia with inhibitors?
  • a) Recombinant FVIa
  • b) Recombinant FVa
  • c) Recombinant FVIIIa
  • d) Recombinant FVIIa
Q.3
Which of the following catalyzes the conversion of prothrombin to thrombin?
  • a) Platelets
  • b) Fibrin
  • c) Pectinase
  • d) Thromboplastin
Q.4
Elimination of disulfide bond between which two amino acid residues within the A3 domain increases FVIII secretion by 2-fold?
  • a) C1414 and C1456
  • b) C1123 and C1158
  • c) C1785 and C1798
  • d) C1899 and C1903
Q.5
The interaction between FVIII and the Endoplasmic Reticulum (ER) chaperone BiP enhances FVIII secretion.
  • a) True
  • b) False
Q.6
Protein-engineered bypassing agents have the potential to treat bleeding in haemophilia patients with inhibitors.
  • a) False
  • b) True
Q.7
Which of the following factors require LMAN1-facilitated transport from the ER to the Golgi?
  • a) FV and FVI
  • b) FVII and FVI
  • c) FVI and FVIII
  • d) FVIII and FV
Q.8
Which of the following enzyme cleaves fibrinogen into fibrin which polymerizes and crosslinks (using factor VIII) into a blood clot?
  • a) Pepsin
  • b) Lipase
  • c) Furin
  • d) Thrombin
Q.9
Furin Cleavage is necessary for FVIII biological functions.
  • a) True
  • b) False
Q.10
Which of the following can inactivate the activated FVIII?
  • a) Inactivated protein B
  • b) Activated protein B
  • c) Inactivated protein C
  • d) Activated protein C
Q.11
Small changes in the amino acid sequence of proteins can have a profound effect on their immunogenicity.
  • a) False
  • b) True
Q.12
Removing which of the following enzyme cleavage site impedes the A2 dissociation?
  • a) Rennin
  • b) Pepsin
  • c) Furin
  • d) Thrombin
Q.13
The potency of gene therapy vectors can be enhanced by using bioengineered extended half-life (EHL) FVIII or FIX fusion proteins as transgenes.
  • a) False
  • b) True
Q.14
How many alternatively spliced transcripts are produced by factor VIII gene?
  • a) Five
  • b) Seven
  • c) Three
  • d) Two
Q.15
APC inactivates FVIIIa by proteolytic cleavage at which of the following sites?
  • a) R313 and/or R512
  • b) R454 and/or R565
  • c) R234 and/or R554
  • d) R336 and/or R562
0 h : 0 m : 1 s