Q.1
Which of the following technology has made it feasible to prepare large quantities of monoclonal antibodies (MAbs) with a defined antigen specificity?
  • a) Southern blotting
  • b) PCR
  • c) rDNA technology
  • d) Hybridoma technology
Q.2
The amino-terminal domains of both heavy and light chains are variable; in that, they differ in amino acid sequence from antibody to antibody.
  • a) False
  • b) True
Q.3
Which of the following domains is responsible for antigen recognition and binding of antigens?
  • a) C domains
  • b) CH1 domain only
  • c) CH1 and CH2 domains
  • d) V domains
Q.4
Which of the following bonds help in the association of antibody H and L chains?
  • a) Peptide bonds
  • b) Ionic bonds
  • c) Hydrogen bonds
  • d) Disulfide bonds
Q.5
The antibody shown in the figure below belongs to which of the following class?
  • a) IgG
  • b) IgD
  • c) IgE
  • d) IgA
Q.6
The hinge region is flexible and susceptible to proteolytic digestion.
  • a) False
  • b) True
Q.7
How many complementarity-determining regions (CDRs) are present in an IgG molecule?
  • a) Three
  • b) Ten
  • c) Six
  • d) Twelve
Q.8
Which of the following is a hybrid molecule that consists of non-identical heavy and light pairs, resulting in two different antigen specificities?
  • a) Chimeric antibody
  • b) Monoclonal antibody
  • c) Humanized antibody
  • d) Bispecific antibody
Q.9
Which of the following is not true for the production of monoclonal antibodies by conventional methods?
  • a) unsuitable for use
  • b) Time-consuming
  • c) Expensive
  • d) Inexpensive
Q.10
The digestion of IgG antibodies with papain produces how many fragments?
  • a) Four
  • b) One
  • c) Two
  • d) Three
Q.11
Which of the following consists of antibody VL fused to a VH by a linker peptide?
  • a) Humanized antibody
  • b) Chimeric antibody
  • c) Fragment of crystallization (Fc)
  • d) Single-chain Variable fragment (ScFv)
Q.12
The antibody shown in the figure below belongs to which of the following class?
  • a) IgG
  • b) IgA
  • c) IgD
  • d) IgM
Q.13
The primary function of the linker in the ScFv molecule is to orientate the V domains into a specific structure to form the active binding site.
  • a) True
  • b) False
Q.14
Which of the following is the cellular receptor of HIV-1 envelope glycoprotein gp120?
  • a) CD12
  • b) CD3
  • c) CD8
  • d) CD4
Q.15
The digestion of IgG antibodies with pepsin produces how many fragments?
  • a) Four
  • b) One
  • c) Three
  • d) Two
0 h : 0 m : 1 s