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Protein Engineering
Protein Engineering Written Test
Quiz 1
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Q.1
Which of the following technology has made it feasible to prepare large quantities of monoclonal antibodies (MAbs) with a defined antigen specificity?
a) Southern blotting
b) PCR
c) rDNA technology
d) Hybridoma technology
Q.2
The amino-terminal domains of both heavy and light chains are variable; in that, they differ in amino acid sequence from antibody to antibody.
a) False
b) True
Q.3
Which of the following domains is responsible for antigen recognition and binding of antigens?
a) C domains
b) CH1 domain only
c) CH1 and CH2 domains
d) V domains
Q.4
Which of the following bonds help in the association of antibody H and L chains?
a) Peptide bonds
b) Ionic bonds
c) Hydrogen bonds
d) Disulfide bonds
Q.5
The antibody shown in the figure below belongs to which of the following class?
a) IgG
b) IgD
c) IgE
d) IgA
Q.6
The hinge region is flexible and susceptible to proteolytic digestion.
a) False
b) True
Q.7
How many complementarity-determining regions (CDRs) are present in an IgG molecule?
a) Three
b) Ten
c) Six
d) Twelve
Q.8
Which of the following is a hybrid molecule that consists of non-identical heavy and light pairs, resulting in two different antigen specificities?
a) Chimeric antibody
b) Monoclonal antibody
c) Humanized antibody
d) Bispecific antibody
Q.9
Which of the following is not true for the production of monoclonal antibodies by conventional methods?
a) unsuitable for use
b) Time-consuming
c) Expensive
d) Inexpensive
Q.10
The digestion of IgG antibodies with papain produces how many fragments?
a) Four
b) One
c) Two
d) Three
Q.11
Which of the following consists of antibody VL fused to a VH by a linker peptide?
a) Humanized antibody
b) Chimeric antibody
c) Fragment of crystallization (Fc)
d) Single-chain Variable fragment (ScFv)
Q.12
The antibody shown in the figure below belongs to which of the following class?
a) IgG
b) IgA
c) IgD
d) IgM
Q.13
The primary function of the linker in the ScFv molecule is to orientate the V domains into a specific structure to form the active binding site.
a) True
b) False
Q.14
Which of the following is the cellular receptor of HIV-1 envelope glycoprotein gp120?
a) CD12
b) CD3
c) CD8
d) CD4
Q.15
The digestion of IgG antibodies with pepsin produces how many fragments?
a) Four
b) One
c) Three
d) Two
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