Q.1
Why is AAV regarded as one of the safest vectors for gene therapy?
  • a) Lack origin
  • b) Helper virus dependent
  • c) Small sized genome
  • d) No toxic effects
Q.2
Where is foreign DNA inserted in an AAV virus vector?
  • a) Cap region
  • b) Rep region
  • c) Inverted repeats
  • d) Origin of replication
Q.3
Which is the only element essential for replication in an AAV vector?
  • a) Origin of replication
  • b) Inverted repeats
  • c) Rep genes
  • d) Cap genes
Q.4
Either endogenous or homologous promoters can be used with an AAV vector.
  • a) True
  • b) False
Q.5
Deletion of which region of an AAV vector abolishes the site-specificity?
  • a) Origin of replication
  • b) Cap region
  • c) Rep region
  • d) Inverted repeats
Q.6
Which of the following type of cells cannot be transfected by AAV vector?
  • a) Liver cells
  • b) Germ cells
  • c) Muscle cells
  • d) Neurons
Q.7
Use of con-catemeric replication intermediates, circumvents which of the most serious disadvantage of AAV vectors?
  • a) Replication ability
  • b) Infection cycle
  • c) DNA carrying capacity
  • d) Host range
Q.8
‘Nuclear occlusion bodies’ are found in _______________
  • a) Baculoviruses
  • b) Adenovirus
  • c) Human somatic cells
  • d) Human germ cells
Q.9
Nuclear occlusion bodies are _____________
  • a) Nuclear particles
  • b) Vitamins
  • c) Proteinaceous particles
  • d) Replication genes
Q.10
Which protein is expressed at high levels in occlusion bodies of baculoviruses?
  • a) Polyhedron
  • b) Amylose
  • c) Glucose
  • d) Lactose
Q.11
The polyhedrin gene of baculovirus vectors cannot be replaced by foreign DNA.
  • a) True
  • b) False
Q.12
AcMNPV vector is a type of __________ which is used for expression in insect cells.
  • a) Baculoviruses
  • b) Adenoviruses
  • c) Caulimoviruses
  • d) Papillomavirus
Q.13
Bombyx mori nuclear polyhedrosis virus infects the _______
  • a) Drosophila
  • b) Plants
  • c) Humans
  • d) Silkworm
Q.14
One limitation of baculovirus expressed system is that ___________ in mammals and insects is different.
  • a) Glycosylation pathway
  • b) Genomic size
  • c) Cloning efficiency
  • d) Virus genre
Q.15
Insect cell lines derived from Estigmene area have the ability of __________
  • a) Post-translational modification
  • b) Replication
  • c) Transduction
  • d) Conjugation
0 h : 0 m : 1 s